Global Gene Expression during the Human Organogenesis: From Transcription...
Human embryogenesis includes an integrated set of complex yet coordinated development of different organs and tissues, which is regulated by the spatiotemporal expression of many genes. Deciphering...
View ArticleCardioprotective Effects of Telmisartan against Heart Failure in Rats Induced...
Angiotensin-converting enzyme-2 (ACE-2) is a homolog of ACE that preferentially forms angiotensin-(ANG)-1-7 from angiotensin II (ANG II). We investigated the cardioprotective effects of telmisartan, a...
View ArticleIL-10-IFN-γ Double Producers CD4+ T Cells Are Induced by Immunization with an...
During the acute phase of infection, T. cruzi replicates extensively and releases immunomodulatory molecules that delay parasite-specific responses mediated by effector T cells. This mechanism of...
View ArticleMolecular Characterization of Porcine MMP19 and MMP23B Genes and Its...
MMP19 and MMP23B belong to the Matrix metalloproteases (MMPs) family, which are zinc-binding endopeptidases that are capable of degrading various components of the extracellular matrix. They are...
View ArticleFRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR...
Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these...
View ArticleA Clinical Overview of Centrosome Amplification in Human Cancers
The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome...
View ArticleStability of a Long Noncoding Viral RNA Depends on a 9-nt Core Element at the...
Kaposi sarcoma-associated herpesvirus (KSHV) ORF57, also known as Mta (mRNA transcript accumulation), enhances viral intron-less transcript accumulation and promotes splicing of intron-containing...
View ArticleGrafting Helps Improve Photosynthesis and Carbohydrate Metabolism in Leaves...
The most important quality for muskmelon (Cucumis melo L.) is their sweetness which is closely related to the soluble sugars content. Leaves are the main photosynthetic organs in plants and thus the...
View ArticleSphingobium Chlorophenolicum Dichlorohydroquinone Dioxygenase (PcpA) Is...
Dichlorohydroquinone dioxygenase (PcpA) is the ring-cleavage enzyme in the PCP biodegradation pathway in Sphingobium chlorophenolicum strain ATCC 39723. PcpA dehalogenates and oxidizes...
View ArticleEarly Exposure to Paraquat Sensitizes Dopaminergic Neurons to Subsequent...
Environmental exposure, genetic modification, and aging are considered risky for Parkinson's disease (PD). How these risk factors cooperate to induce progressive neurodegeneration in PD remains...
View ArticleGlatiramer Acetate Treatment Increases Stability of Spinal Synapses and Down...
The recent discovery that the major histocompatibility complex of class I (MHC I) expression has a role in the synaptic elimination process, represented an insight into understanding the cross talk...
View ArticlePhotoactivation Studies of Zinc Porphyrin-Myoglobin System and Its...
An artificial zinc porphyrin-myoglobin-based photo-chemical energy conversion system, consisting of ZnPP-Mb or ZnPE1-Mb as a photosensitizer, NADP+ as an electron acceptor, and triethanolamine as an...
View ArticleDeletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response...
The aryl hydrocarbon receptor (AhR) is a ligand-activated receptor that mediates the toxicity of environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recently, it has been...
View ArticleA DNA Vaccine Encoding for TcSSP4 Induces Protection against Acute and...
Immunization of mice with plasmids containing genes of Trypanosoma cruzi induces protective immunity in the murine model of Chagas disease. A cDNA clone that codes for an amastigote-specific surface...
View ArticleMacrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan...
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon...
View ArticleThe Increase in Mannose Receptor Recycling Favors Arginase Induction and...
The macrophage mannose receptor (MR) is a pattern recognition receptor of the innate immune system that binds to microbial structures bearing mannose, fucose and N-acetylglucosamine on their surface....
View ArticleTh2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis...
Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to...
View ArticleProtein and Antigen Diversity in the Vesicular Fluid of Taenia Solium...
Cysticercosis caused by Taenia solium is a health threat for humans and pigs living in developing countries, for which there is neither a flawless immunodiagnostic test nor a totally effective...
View ArticleMIF Synergizes with Trypanosoma cruzi Antigens to Promote Efficient Dendritic...
Macrophage migration inhibitory factor (MIF) has been found to be involved in host resistance to several parasitic infections. To determine the mechanisms of the MIF-dependent responses to Trypanosoma...
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